Respiratory recovery trajectories after severe-to-critical COVID-19: a 1-year prospective multicentre study
Frédéric Schlemmer
(1, 2)
,
Simon Valentin
(3, 4)
,
Laurent Boyer
(5, 6)
,
Anne Guillaumot
(3)
,
François Chabot
(3, 4)
,
Clairelyne Dupin
(7)
,
Pierre Le Guen
(8, 7)
,
Gwenael Lorillon
(7)
,
Anne Bergeron
(9)
,
Damien Basille
(10, 11)
,
Julia Delomez
(12)
,
Claire Andrejak
(10, 11)
,
Valentine Bonnefoy
(13)
,
Hélène Goussault
(13)
,
Jean-Baptiste Assié
(14, 15)
,
Pascaline Choinier
(16)
,
Anne-Marie Ruppert
(8)
,
Jacques Cadranel
(8)
,
Maria Chiara Mennitti
(17)
,
Mehdi Roumila
(17)
,
Charlotte Colin
(17)
,
Sven Günther
(18)
,
Olivier Sanchez
(18)
,
Thomas Gille
(19, 20)
,
Lucile Sésé
(19, 20)
,
Yurdagul Uzunhan
(20, 19)
,
Morgane Faure
(21)
,
Maxime Patout
(21, 22)
,
Capucine Morelot-Panzini
(21, 22)
,
Pierantonio Laveneziana
(22, 21)
,
Maeva Zysman
(23, 24)
,
Elodie Blanchard
(23, 24)
,
Chantal Raherison-Semjen
(25, 23, 26)
,
Violaine Giraud
(27)
,
Etienne Giroux-Leprieur
(27, 28)
,
Stéfanie Habib
(29)
,
Nicolas Roche
(29)
,
Anh Tuan Dinh-Xuan
(30)
,
Islem Sifaoui
(1)
,
Pierre-Yves Brillet
(31)
,
Camille Jung
(32)
,
Emmanuelle Boutin
(1, 33)
,
Richard Layese
(1, 33)
,
Florence Canoui-Poitrine
(1, 33)
,
Bernard Maitre
(2, 32)
1
Hôpital Henri Mondor
2 IMRB - Institut Mondor de Recherche Biomédicale
3 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
4 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
5 CEReSS - Centre d'études et de recherche sur les services de santé et la qualité de vie
6 Hôpitaux Sud - Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM]
7 AP-HP - Hopital Saint-Louis [AP-HP]
8 CHU Tenon [AP-HP]
9 HUG - Hôpitaux Universitaires de Genève
10 CHU Amiens-Picardie
11 AGIR - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
12 UPJV - Université de Picardie Jules Verne
13 Service de Pneumologie [CHI Créteil]
14 CEpiA - Clinical Epidemiology and Ageing : Geriatrie Soins Primaires et Santé Publique
15 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers
16 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
17 CHV - Centre Hospitalier de Versailles André Mignot
18 HEGP - Hôpital Européen Georges Pompidou [APHP]
19 Hôpital Avicenne [AP-HP]
20 H&P - U1272 Inserm - Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires
21 CHU Pitié-Salpêtrière [AP-HP]
22 UMRS 1158 - Neurophysiologie Respiratoire Expérimentale et Clinique
23 CRCTB - Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux]
24 Hôpital Haut-Lévêque [CHU Bordeaux]
25 BPH - Bordeaux population health
26 Centre Hospitalier de Basse-Terre [Guadeloupe]
27 Hôpital Ambroise Paré [AP-HP]
28 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
29 IC UM3 (UMR 8104 / U1016) - Institut Cochin
30 Service de physiologie et explorations fonctionelles [CHU Cochin]
31 Service de radiologie [Avicenne]
32 CHIC - Centre Hospitalier Intercommunal de Créteil
33 U955 Inserm - UPEC - IMRB - CEPIA/"Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health" [Créteil]
2 IMRB - Institut Mondor de Recherche Biomédicale
3 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
4 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
5 CEReSS - Centre d'études et de recherche sur les services de santé et la qualité de vie
6 Hôpitaux Sud - Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM]
7 AP-HP - Hopital Saint-Louis [AP-HP]
8 CHU Tenon [AP-HP]
9 HUG - Hôpitaux Universitaires de Genève
10 CHU Amiens-Picardie
11 AGIR - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
12 UPJV - Université de Picardie Jules Verne
13 Service de Pneumologie [CHI Créteil]
14 CEpiA - Clinical Epidemiology and Ageing : Geriatrie Soins Primaires et Santé Publique
15 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers
16 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
17 CHV - Centre Hospitalier de Versailles André Mignot
18 HEGP - Hôpital Européen Georges Pompidou [APHP]
19 Hôpital Avicenne [AP-HP]
20 H&P - U1272 Inserm - Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires
21 CHU Pitié-Salpêtrière [AP-HP]
22 UMRS 1158 - Neurophysiologie Respiratoire Expérimentale et Clinique
23 CRCTB - Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux]
24 Hôpital Haut-Lévêque [CHU Bordeaux]
25 BPH - Bordeaux population health
26 Centre Hospitalier de Basse-Terre [Guadeloupe]
27 Hôpital Ambroise Paré [AP-HP]
28 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
29 IC UM3 (UMR 8104 / U1016) - Institut Cochin
30 Service de physiologie et explorations fonctionelles [CHU Cochin]
31 Service de radiologie [Avicenne]
32 CHIC - Centre Hospitalier Intercommunal de Créteil
33 U955 Inserm - UPEC - IMRB - CEPIA/"Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health" [Créteil]
Frédéric Schlemmer
- Function : Author
- PersonId : 1220207
- ORCID : 0000-0003-2113-7113
Simon Valentin
- Function : Author
- PersonId : 1220208
- ORCID : 0000-0002-9304-1359
Clairelyne Dupin
- Function : Author
- PersonId : 1169550
- ORCID : 0000-0001-7957-8195
Pierre Le Guen
- Function : Author
- PersonId : 1220209
- ORCID : 0000-0001-8608-4484
Damien Basille
- Function : Author
- PersonId : 1220210
- ORCID : 0000-0001-8979-9792
- IdRef : 152558500
Claire Andrejak
- Function : Author
- PersonId : 1144520
- IdHAL : claire-andrejak
Thomas Gille
- Function : Author
- PersonId : 1220211
- ORCID : 0000-0002-1577-6595
Yurdagul Uzunhan
- Function : Author
- PersonId : 770334
- ORCID : 0000-0002-1607-1407
- IdRef : 093404778
Maxime Patout
- Function : Author
- PersonId : 784923
- ORCID : 0000-0002-1366-8726
- IdRef : 181645335
Pierantonio Laveneziana
- Function : Author
- PersonId : 1220212
- ORCID : 0000-0002-1002-2161
Elodie Blanchard
- Function : Author
- PersonId : 1220213
- ORCID : 0000-0001-5445-9122
Anh Tuan Dinh-Xuan
- Function : Author
- PersonId : 1220214
- ORCID : 0000-0001-8651-5176
Abstract
Background Survivors of severe-to-critical COVID-19 may have functional impairment, radiological sequelae and persistent symptoms requiring prolonged follow-up. This pragmatic study aimed to describe their clinical follow-up and determine their respiratory recovery trajectories, and factors that could influence them and their health-related quality of life. Methods Adults hospitalised for severe-to-critical COVID-19 were evaluated at 3 months and up to 12 months post-hospital discharge in this prospective, multicentre, cohort study. Results Among 485 enrolled participants, 293 (60%) were reassessed at 6 months and 163 (35%) at 12 months; 89 (51%) and 47 (27%) of the 173 ones initially managed with standard oxygen were reassessed at 6 and 12 months, respectively. At 3 months, 34%, 70% and 56% of the participants had a restrictive lung defect, impaired DL CO and significant radiological sequelae, respectively. During extended follow-up, DL CO and FVC (% of predicted value) increased by means of +4 points at 6 months, and +6 points at 12 months. Sex, body mass index, chronic respiratory disease, immunosuppression, pneumonia extent or corticosteroid use during acute COVID-19 and prolonged invasive mechanical ventilation (IMV) were associated with DL CO at month 3, but not its trajectory thereafter. Among 475 (98%) patients with at least one chest computed-tomography scan during follow-up, 196 (41%) had significant sequelae on their last images. Conclusion Although pulmonary function and radiological abnormalities improved up to 1 year post-acute-COVID-19, high percentages of severe-to-critical disease survivors, including a notable proportion of those managed with standard oxygen, had significant lung sequelae and residual symptoms justifying prolonged follow-up.
Domains
Human health and pathology
Origin : Publisher files allowed on an open archive
licence : CC BY NC - Attribution - NonCommercial
licence : CC BY NC - Attribution - NonCommercial