Abstract How swine influenza viruses enzootic persistence within farrow-to-finish pig farms can be controlled? The benefits from modelling Farrow-to-finish pig farms are frequently infected by several subtypes of swine influenza A viruses (swIAV) which have become enzootic in pig populations and responsible for influenza outbreaks repeating permanently on each batch, at a similar age. Once settled within the farm, these viruses have the ability to maintain durably within the population and veterinarians lack efficient control tools to get rid of them. A stochastic metapopulation model representing the co-circulation of two swIAV in a farrow-to-finish pig farm has been developed with the aim of evaluating the ability of control strategies related to rearing conditions and vaccination to break the infection cycle. Although vaccination of the breeding herd was found beneficial, significantly reducing the persistence of the virus in this subpopulation, it didn't achieve swIAV fade-out at the whole population level (the infection was persisting in the growing pig subpopulation). The externalisation of batches of growing pigs at weaning was found as the most efficient strategy to break down the mechanic repetition of infections between batches.