Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021) - Anses - Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail Access content directly
Journal Articles International Journal of Hygiene and Environmental Health Year : 2023

Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)

Eva Govarts (1) , Liese Gilles (1) , Laura Rodriguez Martin (1) , Tiina Santonen (2) , Petra Apel (3) , Paula Alvito , Elena Anastasi , Helle Raun Andersen , Anna-Maria Andersson , Lenka Andryskova , Jean-Philippe Antignac , Brice Appenzeller , Fabio Barbone , Zohar Barnett-Itzhaki , Robert Barouki , Tamar Berman , Wieneke Bil , Teresa Borges , Jurgen Buekers , Ana Cañas-Portilla , Adrian Covaci , Zsofia Csako , Elly den Hond , Darina Dvorakova , Lucia Fabelova , Tony Fletcher , Hanne Frederiksen , Catherine Gabriel , Catherine Ganzleben , Thomas Göen , Thorhallur I Halldorsson , Line S Haug , Milena Horvat , Pasi Huuskonen , Medea Imboden , Marta Jagodic Hudobivnik , Beata Janasik , Natasa Janev Holcer , Spyros Karakitsios , Andromachi Katsonouri , Jana Klanova , Venetia Kokaraki , Tina Kold Jensen , Jani Koponen , Michelle Laeremans , Federica Laguzzi , Rosa Lange , Nora Lemke , Sanna Lignell , Anna Karin Lindroos , Joana Lobo Vicente , Mirjam Luijten , Konstantinos C Makris , Darja Mazej , Lisa Melymuk , Matthieu Meslin (4) , Hans Mol , Parisa Montazeri , Aline Murawski , Sónia Namorado , Lars Niemann , Stefanie Nübler , Baltazar Nunes , Kristin Olafsdottir , Lubica Palkovicova Murinova , Nafsika Papaioannou , Susana Pedraza-Diaz , Pavel Piler , Veronika Plichta , Michael Poteser , Nicole Probst-Hensch , Loïc Rambaud , Elke Rauscher-Gabernig , Katarina Rausova , Sylvie Remy , Margaux Riou , Valentina Rosolen , Christophe Rousselle , Maria Rüther , Denis Sarigiannis , Maria J Silva , Zdenka Šlejkovec , Janja Snoj Tratnik , Anja Stajnko , Tamas Szigeti , José V Tarazona , Cathrine Thomsen , Žiga Tkalec , Hanna Tolonen , Tomas Trnovec , Maria Uhl , An van Nieuwenhuyse , Elsa Vasco , Veerle J Verheyen , Susana Viegas , Anne Marie Vinggaard , Nina Vogel , Katrin Vorkamp , Wojciech Wasowicz , Till Weber , Sona Wimmerova , Marjolijn Woutersen , Philipp Zimmermann , Martin Zvonar , Holger Koch , Marike Kolossa-Gehring , Marta Esteban López , Argelia Castaño , Lorraine Stewart , Ovnair Sepai , Greet Schoeters (1)
Paula Alvito
  • Function : Author
Elena Anastasi
  • Function : Author
Helle Raun Andersen
  • Function : Author
Anna-Maria Andersson
  • Function : Author
Lenka Andryskova
  • Function : Author
Jean-Philippe Antignac
Brice Appenzeller
  • Function : Author
Fabio Barbone
  • Function : Author
Zohar Barnett-Itzhaki
  • Function : Author
Robert Barouki
Tamar Berman
  • Function : Author
Wieneke Bil
  • Function : Author
Teresa Borges
  • Function : Author
Jurgen Buekers
  • Function : Author
Ana Cañas-Portilla
  • Function : Author
Adrian Covaci
  • Function : Author
Zsofia Csako
  • Function : Author
Elly den Hond
  • Function : Author
Darina Dvorakova
  • Function : Author
Lucia Fabelova
  • Function : Author
Tony Fletcher
  • Function : Author
Hanne Frederiksen
  • Function : Author
Catherine Gabriel
  • Function : Author
Catherine Ganzleben
  • Function : Author
Thomas Göen
  • Function : Author
Thorhallur I Halldorsson
  • Function : Author
Line S Haug
  • Function : Author
Milena Horvat
  • Function : Author
Pasi Huuskonen
  • Function : Author
Medea Imboden
  • Function : Author
Marta Jagodic Hudobivnik
  • Function : Author
Beata Janasik
  • Function : Author
Natasa Janev Holcer
  • Function : Author
Spyros Karakitsios
  • Function : Author
Andromachi Katsonouri
  • Function : Author
Jana Klanova
  • Function : Author
Venetia Kokaraki
  • Function : Author
Tina Kold Jensen
  • Function : Author
Jani Koponen
  • Function : Author
Michelle Laeremans
  • Function : Author
Federica Laguzzi
  • Function : Author
Rosa Lange
  • Function : Author
Nora Lemke
  • Function : Author
Sanna Lignell
  • Function : Author
Anna Karin Lindroos
  • Function : Author
Joana Lobo Vicente
  • Function : Author
Mirjam Luijten
  • Function : Author
Konstantinos C Makris
  • Function : Author
Darja Mazej
  • Function : Author
Lisa Melymuk
  • Function : Author
Hans Mol
  • Function : Author
Parisa Montazeri
  • Function : Author
Aline Murawski
  • Function : Author
Sónia Namorado
  • Function : Author
Lars Niemann
  • Function : Author
Stefanie Nübler
  • Function : Author
Baltazar Nunes
  • Function : Author
Kristin Olafsdottir
  • Function : Author
Lubica Palkovicova Murinova
  • Function : Author
Nafsika Papaioannou
  • Function : Author
Susana Pedraza-Diaz
  • Function : Author
Pavel Piler
  • Function : Author
Veronika Plichta
  • Function : Author
Michael Poteser
  • Function : Author
Nicole Probst-Hensch
  • Function : Author
Loïc Rambaud
  • Function : Author
Elke Rauscher-Gabernig
  • Function : Author
Katarina Rausova
  • Function : Author
Sylvie Remy
  • Function : Author
Margaux Riou
  • Function : Author
Valentina Rosolen
  • Function : Author
Christophe Rousselle
  • Function : Author
Maria Rüther
  • Function : Author
Denis Sarigiannis
  • Function : Author
Maria J Silva
  • Function : Author
Zdenka Šlejkovec
  • Function : Author
Janja Snoj Tratnik
  • Function : Author
Anja Stajnko
  • Function : Author
Tamas Szigeti
  • Function : Author
José V Tarazona
  • Function : Author
Cathrine Thomsen
  • Function : Author
Žiga Tkalec
  • Function : Author
Hanna Tolonen
  • Function : Author
Tomas Trnovec
  • Function : Author
Maria Uhl
  • Function : Author
An van Nieuwenhuyse
  • Function : Author
Elsa Vasco
  • Function : Author
Veerle J Verheyen
  • Function : Author
Susana Viegas
  • Function : Author
Anne Marie Vinggaard
  • Function : Author
Nina Vogel
  • Function : Author
Katrin Vorkamp
  • Function : Author
Wojciech Wasowicz
  • Function : Author
Till Weber
  • Function : Author
Sona Wimmerova
  • Function : Author
Marjolijn Woutersen
  • Function : Author
Philipp Zimmermann
  • Function : Author
Martin Zvonar
  • Function : Author
Holger Koch
  • Function : Author
Marike Kolossa-Gehring
  • Function : Author
Marta Esteban López
  • Function : Author
Argelia Castaño
  • Function : Author
Lorraine Stewart
  • Function : Author
Ovnair Sepai
  • Function : Author

Abstract

As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6-12 years, (ii) 3,117 teenagers aged 12-18 years and (iii) 4,102 young adults aged 20-39 years. The participants were recruited between 2014 and 2021 in 11-12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educational attainment. Geographical variations were seen for all exposure biomarkers. For 15 biomarkers, the available health-based HBM guidance values were exceeded with highest exceedance rates for toxicologically relevant arsenic in teenagers (40%), 3-PBA in children (36%), and between 11 and 14% for total DON, Σ (PFOA + PFNA + PFHxS + PFOS), bisphenol S and cadmium. The infrastructure and harmonized approach succeeded in obtaining comparable European wide internal exposure data for a prioritized set of 11 chemical groups. These data serve as a reference for comparison at the global level, provide a baseline to compare the efficacy of the European Commission's chemical strategy for sustainability and will give leverage to national policy makers for the implementation of targeted measures.
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anses-03996834 , version 1 (20-02-2023)

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Eva Govarts, Liese Gilles, Laura Rodriguez Martin, Tiina Santonen, Petra Apel, et al.. Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021). International Journal of Hygiene and Environmental Health, 2023, 249, pp.114119. ⟨10.1016/j.ijheh.2023.114119⟩. ⟨anses-03996834⟩

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