Combined in silico and in vitro approaches to identify P‐glycoprotein‐inhibiting pesticides
Résumé
The P-glycoprotein (P-gp) efflux pump plays a major role in xenobiotic detoxification. The inhibition of its activity by environmental contaminants remains however rather little characterised. The present study was designed to develop a combination of different approaches to identify P-gp inhibitors among a large number of pesticides using in silico and in vitro models. First, the prediction performance of four web tools was evaluated alone or in combination using a set of recently marketed drugs.
| Origine | Publication financée par une institution |
|---|---|
| Licence |
