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            <title xml:lang="en">Turmeric to fight against coccidia: a disappointing candidate</title>
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                <forename type="first">Jean-Michel</forename>
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                <title xml:lang="en">Turmeric to fight against coccidia: a disappointing candidate</title>
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                    <forename type="first">Christophe</forename>
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                  <date type="start">2024-03-20</date>
                  <date type="end">2024-03-21</date>
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                <term xml:lang="fr">Eimeria</term>
                <term xml:lang="fr">Extraits de curcuma</term>
                <term xml:lang="fr">Coccidiose aviaire</term>
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              <p>Among the poultry parasites, coccidia are responsible for the greatest economic losses. Targeted control methods are anticoccidial feed additives, anticoccidial vaccines, anticoccidial veterinary drugs and disinfectants effective against oocysts. Anticoccidial feed additives, the most used approach, face problems of resistance and a negative image. Plant based products are a considered alternative to get rid of coccidiostats. In this context, we studied in an experimental infection model, the effect of curcuma extracts which are mentioned in the literature for having an interest for the control of coccidiosis. Three trials were conducted in protected facilities with Eimeria acervulina and/or Eimeria tenella challenge. The two first trials aimed to study the activity of extracts obtained from two different extraction methods (sub-critical water and water alcohol macerate) incorporated in feed. In the third trial, a sub-critical water extract was given by oral gavage. Bodyweight, body weight gain, morbidity, faecal aspect, and oocyst production were measured and analysed. Coccidia lesions were recorded seven days after infection. The results of the three trials indicate an almost complete absence of effect of the curcuma extracts against the two coccidia species, except in one trial showing an intermediate effect on weight gain. These conclusions greatly differ from those of previous studies. Actually, the conditions for obtaining the curcuma extracts and their composition may vary and their use with other ingredients can lead to different effects.</p>
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              <p>Parmi les parasites des volailles, les coccidies sont responsables des pertes économiques les plus importantes. Les moyens autorisés de lutte ciblée sont les additifs coccidiostatiques, les vaccins anticoccidiens, des médicaments vétérinaires actifs sur les coccidies et des désinfectants oocysticides. Les additifs coccidiostatiques, les plus utilisés, sont confrontés à des problèmes de résistance et une image négative. Les produits à base de plantes sont une alternative envisagée pour s’affranchir des anticoccidiens. Dans cette perspective, nous avons étudié, en infection expérimentale, l’effet d’extraits de curcuma qui est décrit dans la littérature comme ayant un intérêt pour le contrôle des coccidioses. Trois essais ont été conduits en animalerie protégée avec infection avec Eimeria acervulina et / ou Eimeria tenella. Les deux premiers essais avaient pour but d’étudier l’activité d’extraits issus de deux modes d’extraction différents (eau subcritique etmacération hydroalcoolique) et incorporés dans l’aliment. Dans le troisième essai, l’extrait obtenu en eau subcritique était administré par gavage. Les poids, les gains de poids, la morbidité, l’aspect des matières fécales et l’excrétion d’oocystes ont été enregistrés et analysés. Les lésions coccidiennes ont été notées sept jours après l’infection. Les résultats des trois essais indiquent une absence quasi-totale d’effet des extraits de curcuma pour les deux coccidies, à part dans un essai où un effet sur le gain de poids est intermédiaire. Ces conclusions diffèrent beaucoup de celles des travaux antérieurs. En effet, les conditions d’obtention et la composition des extraits de curcuma utilisés peuvent varier et leur utilisation avec d’autres ingrédients peut entraîner des effets différents.</p>
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