Exceptional Bluetongue virus (BTV) and Epizootic hemorrhagic disease virus (EHDV) circulation in France in 2023 - Anses - Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail
Journal Articles Virus Research Year : 2024

Exceptional Bluetongue virus (BTV) and Epizootic hemorrhagic disease virus (EHDV) circulation in France in 2023

Mathilde Gondard
Connectez-vous pour contacter l'auteur
Lydie Postic
Emmanuel Bréard
Fabien Vorimore
Bernd Hoffmann
Charlotte Warembourg
  • Function : Author
Giovanni Savini
  • Function : Author
Alessio Lorusso
  • Function : Author
Maurilia Marcacci
  • Function : Author
Stephan Zientara
  • Function : Author
Damien Vitour
  • Function : Author

Abstract

Bluetongue (BT) and Epizootic Hemorrhagic Disease (EHD) are two notifiable animal diseases transmitted to ruminants by small hematophagous midges belonging to the Culicoides genus. The etiological agents, Bluetongue virus (BTV) and Epizootic hemorrhagic disease virus (EHDV), are both members of the Sedoreoviridae family and Orbivirus genus, which include double-stranded (ds) RNA segmented genomes (10 segments). By the end of the summer 2023, first's outbreaks of EHD were reported from the south west of France, concurrently with unexpectedly severe BT cases in Central France and Corsica. Within a few weeks, numerous BT and EHD outbreaks were recorded with significant sanitary and economic impact on cattle and sheep farms (no sanitary impact of EHD for sheep). Using a customized SISPA approach and the nanopore sequencing technology we successfully recovered genomic sequences from viral isolates and blood samples from infected animals from EHD and BT outbreaks. Three different viruses were responsible for these outbreaks: EHDV-8, BTV-8 and BTV-4. The EHDV-8 strain detected in France corresponded to the strain circulating in Tunisia, Sardinia and Spain since 2021 and 2022. A new BTV-8 strain of unknown origin, clearly different from the enzootic strain circulating in France since 2015, was responsible of the BT outbreaks in domestic ruminants in 2023 on both mainland France and Corsica. A second BTV, BTV-4, also involved in BT outbreaks in Corsica, corresponded to a BTV-4 strain occasionally detected on Corsica island since 2016, suggesting either a new introduction of this strain or a silent circulation on the field. The exceptional nature of orbivirus epizootics in France in 2023, including new introduction, emergence or incursions, raises numerous questions regarding BTV and EHDV dynamics and epidemiology and stresses out the need to identify factors involved in these emergences.
Fichier principal
Vignette du fichier
1-s2.0-S0168170224001825-main.pdf (6.35 Mo) Télécharger le fichier
Origin Publication funded by an institution
Licence

Dates and versions

anses-04793042 , version 1 (20-11-2024)

Licence

Identifiers

Cite

Mathilde Gondard, Lydie Postic, Emmanuel Garin, Emmanuel Bréard, Mathilde Turpaud, et al.. Exceptional Bluetongue virus (BTV) and Epizootic hemorrhagic disease virus (EHDV) circulation in France in 2023. Virus Research, 2024, 350, pp.199489. ⟨10.1016/j.virusres.2024.199489⟩. ⟨anses-04793042⟩
0 View
0 Download

Altmetric

Share

More