Broad range molecular detection methods identify only Borrelia spp. in erythema migrans biopsies and blood of tick-bitten patients

In this multicenter study conducted in France, we challenged the hypothesis of the transmission of pathogens other than Borrelia spp. in 22 patients developing erythema migrans following a tick bite. Using a combination of high-throughput microfluidic PCRs and agnostic metagenomics on skin biopsies and blood samples, no microorganisms other than Borrelia spp. was found.

Keywords

Ticks Lyme disease Erythema migrans Metagenomics RT-PCR Pathogen discovery

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Life Sciences [q-bio]

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1-s2.0-S235277142400212X-main.pdf (412.7 Ko)

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Philippe Pérot : Connect in order to contact the contributor

https://hal.inrae.fr/hal-04693283

Submitted on : Thursday, September 12, 2024-9:56:43 AM

Last modification on : Monday, September 16, 2024-1:30:05 PM

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hal-04693283 , version 1 (12-09-2024)

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HAL Id : hal-04693283 , version 1
DOI : 10.1016/j.onehlt.2024.100886

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Philippe Pérot, Laura Tondeur, Sara Moutailler, Delphine Chrétien, Nicole Corre-Catelin, et al.. Broad range molecular detection methods identify only Borrelia spp. in erythema migrans biopsies and blood of tick-bitten patients. One Health, 2024, 19, pp.100886. ⟨10.1016/j.onehlt.2024.100886⟩. ⟨hal-04693283⟩

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