index - Laboratoire de recherche européen pour la polyarthrite rhumatoïde Access content directly

EUROPEAN RESEARCH LABORATORY FOR RHEUMATOID ARTHRITIS – GENHOTEL

European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

Documents avec texte intégral

32

Références bibliographiques

80

Mots-clés

HLA-DR Antigens Algeria Autoantibodies Family Metabolic reprogramming Anti-citrullinated protein antibodies APOPTOSIS Databases Antibodies Logical modelling African Continental Ancestry Group Non-Receptor Type 22 Environment Genetic Age of Onset Europe Binding Sites Reproducibility Complex genetic disease Autoimmune thyroid diseases Linkage Disequilibrium Female Biocuration Polymorphism Tunisia Hybrid modeling Biosensor Animals Epitopes PTPN22 gene Adolescent Risk Factors Genetic Association Studies Antigen Presentation Biological pathway Haplotypes Humans Shared Epitope Autoimmune Diseases 80 and over HLA-DRB1 RHEUMATOID ARTHRITIS Disease maps Association study Analysis Phenotype Anti-Idiotypic Rheumatoid Arthritis Patient Ankylosing Genetic Predisposition to Disease Autoantibody Production Computational biology Génétique Autoimmune thyroid disease Transcriptome Receptors France Biologie computationnelle des systèmes Gene Frequency Annotation standards Computational modeling European Continental Ancestry Group Genetics POLYMORPHISM Rheumatoid Young Adult Antigens ATP Binding Cassette Transporter Polyarthrite rhumatoïde Biologie des systèmes Family Health Autoimmunity Middle Aged Age Factors Male Rheumatoid arthritis Rheumatoid Factor Case-Control Studies Genetic Linkage HLA-DRB1 Chains Arthritis Algerian population Alleles Genotype Ankylosing spondylitis Odds Ratio Antirheumatic Agents Network inference Biomarkers Aged Protein Tyrosine Phosphatase In silico simulations Single Nucleotide Adult Computational systems biology Systems biology Rheumatoid Arthritis ABCB1 ASSOCIATION STUDY Cohort Studies

Derniers dépôts

Chargement de la page

Collaboration à l'international