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European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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Age Factors Binding Sites Databases Risk Factors Disease maps Rheumatoid Factor Aged Europe Génétique African Continental Ancestry Group Boolean networks Breast cancer Analysis Humans Receptors Genetic Linkage Reproducibility Computational systems biology HLA-DRB1 Chains Middle Aged PTPN22 gene France Anti-Idiotypic Alleles ABCB1 Systems biology Ankylosing Network inference Autoimmune thyroid disease Phenotype Adult Epitopes Tunisia Linkage Disequilibrium Biologie computationnelle des systèmes Young Adult Complex genetic disease Rheumatoid arthritis Genetics Female Rheumatoid Arthritis Patient RHEUMATOID ARTHRITIS ASSOCIATION STUDY Biomarkers Antirheumatic Agents Anti-citrullinated protein antibodies Genotype Autoimmune Diseases Annotation standards Autoantibodies Autoimmunity Biologie des systèmes Antigens Logical modelling POLYMORPHISM Ankylosing spondylitis Case-Control Studies European Continental Ancestry Group Genetic Predisposition to Disease Autoimmune thyroid diseases HLA-DRB1 Biocuration Shared Epitope Rheumatoid HLA-DR Antigens Adolescent Antigen Presentation Family Health ATP Binding Cassette Transporter Algerian population Boolean models Algeria Genetic Association Studies Male Polymorphism Autoantibody Production Biological pathway Animals APOPTOSIS Cohort Studies Metabolic reprogramming Polyarthrite rhumatoïde Environment Association study Antibodies Non-Receptor Type 22 Genetic Arthritis Gene Frequency Boolean simulations Single Nucleotide Age of Onset Haplotypes Family In silico simulations 80 and over Computational modeling Protein Tyrosine Phosphatase Odds Ratio Rheumatoid Arthritis

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