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European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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Anti-citrullinated protein antibodies Receptors Algeria In silico simulations Rheumatoid arthritis Arthritis African Continental Ancestry Group Autoimmune Diseases Europe Breast cancer Risk Factors Gene Frequency Rheumatoid Biomarkers POLYMORPHISM Tunisia ABCB1 Biocuration Autoimmunity Young Adult APOPTOSIS Autoantibody Production 80 and over Phenotype Humans HLA-DR Antigens Age of Onset PTPN22 gene Computational systems biology Biologie des systèmes Génétique Network inference Cohort Studies ATP Binding Cassette Transporter Animals Rheumatoid Arthritis Disease maps Autoantibodies Polyarthrite rhumatoïde Analysis Boolean models Genetic Linkage Case-Control Studies Ankylosing spondylitis Biological pathway Reproducibility Antigen Presentation Polymorphism Rheumatoid Arthritis Patient Antirheumatic Agents Antigens Adolescent Middle Aged Metabolic reprogramming Rheumatoid Factor HLA-DRB1 Genetic Algerian population Binding Sites Autoimmune thyroid diseases Protein Tyrosine Phosphatase Haplotypes France Computational modeling Biologie computationnelle des systèmes Genotype Epitopes Antibodies Single Nucleotide Odds Ratio Family Health Shared Epitope Adult RHEUMATOID ARTHRITIS Age Factors Family Alleles Male Anti-Idiotypic Databases Boolean simulations Association study Logical modelling Genetics Ankylosing Boolean networks ASSOCIATION STUDY Genetic Predisposition to Disease Linkage Disequilibrium Genetic Association Studies Autoimmune thyroid disease European Continental Ancestry Group Environment Systems biology Female Complex genetic disease HLA-DRB1 Chains Non-Receptor Type 22 Aged Annotation standards

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