Phylogenomic Perspective on a Unique Mycobacterium bovis Clade Dominating Bovine Tuberculosis Infections among Cattle and Buffalos in Northern Brazil - Anses - Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail Access content directly
Journal Articles Scientific Reports Year : 2020

Phylogenomic Perspective on a Unique Mycobacterium bovis Clade Dominating Bovine Tuberculosis Infections among Cattle and Buffalos in Northern Brazil

María Laura Boschiroli
Lorraine Michelet

Abstract

Lack of routine surveillance in countries endemic for bovine tuberculosis (TB) and limited laboratory support contributes to the inability to differentiate the Mycobacterium tuberculosis Complex species, leading to an underestimated burden of the disease. Here, Whole-Genome Sequencing of Mycobacterium bovis isolated from tissues with TB-like lesions obtained from cattle and buffalos at Marajó Island, Brazil, demonstrates that recent transmission of M. bovis is ongoing at distinct sites. Moreover, the M. bovis epidemiology in this setting is herein found to be dominated by an endemic and unique clade composed of strains evolved from a common ancestor that are now genetically differentiated from other M. bovis clades. Additionally, envisioning a rapid strain differentiation and tracing across multiple settings, 28 globally validated strain-specific SNPs were identified, three of which considered as robust markers for the M. bovis Marajó strain. In conclusion, this study contributes with data regarding the identification of a novel M. bovis phylogenetic clade responsible for ongoing transmission events in both cattle and buffalo species in Brazil, provides a framework to investigate the dissemination of this highly prevalent strain and, holds the potential to inform TB control strategies that may help to prevent the spread of bovine and zoonotic TB.
Fichier principal
Vignette du fichier
2020_deConceicao_SciRep.pdf (3.47 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

anses-03910880 , version 1 (22-12-2022)

Licence

Attribution

Identifiers

Cite

Marília Lima Da Conceição, Emilyn Costa Conceição, Ismari Perini Furlaneto, Sandro Patroca Da Silva, Arthur Emil dos Santos Guimarães, et al.. Phylogenomic Perspective on a Unique Mycobacterium bovis Clade Dominating Bovine Tuberculosis Infections among Cattle and Buffalos in Northern Brazil. Scientific Reports, 2020, 10 (1), pp.1747. ⟨10.1038/s41598-020-58398-5⟩. ⟨anses-03910880⟩

Collections

ANSES RIIP
14 View
42 Download

Altmetric

Share

Gmail Facebook X LinkedIn More