Safety evaluation of the food enzyme d‐tagatose 3‐epimerase from the genetically modified Escherichia coli strain PS‐Sav‐001 - Anses - Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail Access content directly
Journal Articles EFSA Journal Year : 2023

Safety evaluation of the food enzyme d‐tagatose 3‐epimerase from the genetically modified Escherichia coli strain PS‐Sav‐001

Claude Lambré
  • Function : Author
José Manuel Barat Baviera
  • Function : Author
Claudia Bolognesi
  • Function : Author
Pier Sandro Cocconcelli
  • Function : Author
Riccardo Crebelli
  • Function : Author
David Michael Gott
  • Function : Author
Konrad Grob
  • Function : Author
Evgenia Lampi
  • Function : Author
Marcel Mengelers
  • Function : Author
Alicja Mortensen
  • Function : Author
Gilles Rivière
Inger‐lise Steffensen
  • Function : Author
Christina Tlustos
  • Function : Author
Henk van Loveren
  • Function : Author
Laurence Vernis
  • Function : Author
Holger Zorn
  • Function : Author
Boet Glandorf
  • Function : Author
Lieve Herman
  • Function : Author
Magdalena Andryszkiewicz
  • Function : Author
Ana Gomes
  • Function : Author
Yi Liu
  • Function : Author
Silvia Peluso
  • Function : Author
Andrew Chesson
  • Function : Author

Abstract

Abstract The food enzyme d‐tagatose 3‐epimerase (EC 5.1.3.31) is produced with the genetically modified Escherichia coli strain PS‐Sav‐001 by SAVANNA Ingredients GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is considered free from viable cells of the production organism and its DNA. The food enzyme is used while retained inside a membrane reactor to convert d‐fructose into the speciality carbohydrate d‐allulose (syn. d‐psicose). Since residual amounts of total organic solids (TOS) are removed by the purification steps applied during the production of d‐allulose, dietary exposure was not calculated and toxicological studies were not considered necessary. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that under the intended conditions of use, the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.

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anses-03997202 , version 1 (20-02-2023)

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Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, et al.. Safety evaluation of the food enzyme d‐tagatose 3‐epimerase from the genetically modified Escherichia coli strain PS‐Sav‐001. EFSA Journal, 2023, 21 (2), pp.10. ⟨10.2903/j.efsa.2023.7752⟩. ⟨anses-03997202⟩

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