A plausibility database summarizing the level of evidence regarding the hazards induced by the exposome on children health - Anses - Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail Access content directly
Journal Articles International Journal of Hygiene and Environmental Health Year : 2024

A plausibility database summarizing the level of evidence regarding the hazards induced by the exposome on children health

Amélie Crépet
Sanchez Margaux
Julien Jean
  • Function : Author
  • PersonId : 1333721
  • IdRef : 129972010
Matteo Redaelli
Karine Angeli
  • Function : relator_co_last_author

Abstract

Childhood diseases correspond to major public health issues. A large number of studies using different approaches provide evidence regarding effects of environmental exposures, encompassed in the exposome, on children's health. We aimed to summarize the overall level of evidence (LoE) from all streams of evidence regarding exposome effects on child health. For 88 selected chemical and urban factors, we retrieved the conclusions of agency reports or literature reviews published between 2015 and 2021 regarding effects on child health, including cardiovascular, metabolic, neurodevelopmental, respiratory and other health outcomes. Adapted versions of PRISMA flowchart and AMSTAR-2 tool were used to select and assess the quality of the systematic reviews retrieved from PubMed and SCOPUS databases. For each factor-outcome pair, conclusions in three streams of evidence (epidemiological, toxicological and mechanistic, the latter corresponding to in vitro and in silico approaches) were translated into stream-specific LoEs and then combined into an overall LoE ranging from "very unlikely" to "very likely". The 88 environmental factors were implied in 611 factor-outcome pairs. Forty-four pairs (7%), corresponding to 16 factors, had a very likely overall LoE (≥80%); 127 pairs (21%), corresponding to 49 factors, had a likely or more overall LoE (≥60%). For 81 pairs (13%), no evidence was available in agency reports or published reviews, while for 275 pairs (45%), corresponding to 68 factors, the overall LoE was very unlikely (<20%). Exposure factors with the greatest number of associated health outcomes with a high overall LoE were HCB, PCBs, temperature (8 outcomes), PFOA (7 outcomes), PFOS, cotinine (6 outcomes), arsenic, lead (5 outcomes), bisphenols A and S, PFNA and PM2.5 (4 outcomes), DDT, DDE and DDD, PFHxA, PFDA, green space, UV radiation (3 outcomes). We developed an approach to extract and summarize the existing evidence about effects of environmental factors on health. The plausibility database built for children's health can be used to identify research gaps, conduct quantitative risk assessment studies. It could be expanded to consider a larger fraction of the exposome and other age groups and should be updated on a regular basis.
Fichier principal
Vignette du fichier
Colzin_Int J Hyg Environ Health_2024.pdf (3.71 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Licence : CC BY NC ND - Attribution - NonCommercial - NoDerivatives

Dates and versions

anses-04425260 , version 1 (05-03-2024)

Licence

Attribution - NonCommercial - NoDerivatives

Identifiers

Cite

Stacy Colzin, Amélie Crépet, Blanche Wies, Audrey Rocabois, Sanchez Margaux, et al.. A plausibility database summarizing the level of evidence regarding the hazards induced by the exposome on children health. International Journal of Hygiene and Environmental Health, 2024, 256, pp.114311. ⟨10.1016/j.ijheh.2023.114311⟩. ⟨anses-04425260⟩

Collections

ANSES UGA CNRS
34 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More