Biosafety of DNA vaccines: New generation of DNA vectors and current knowledge on the fate of plasmids after injection. - Anses - Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail Access content directly
Journal Articles Vaccine Year : 2010

Biosafety of DNA vaccines: New generation of DNA vectors and current knowledge on the fate of plasmids after injection.

Abstract

DNA vaccination has been widely studied to develop new, alternative, efficient and safe vaccines for humans and animals. Many efforts have been made to increase the immunising potential of these vaccines and three veterinary vaccines are now available on the market. Much work is also being dedicated to develop effective DNA vaccines for humans. However, this new vaccination technique raises issues concerning biosafety due to the nature of the vector, i.e. a DNA molecule that contains sequences of prokaryotic origin (e.g. genes for antibiotic resistance). This review describes the development of the new generation of DNA vectors that are partially or completely devoid of elements of prokaryotic origin and outlines the results of studies on the fate of plasmids after their injection in vivo.

Domains

Vaccinology
Fichier principal
Vignette du fichier
Author_s_Manuscript_Faurez_et_al_-JVAC-2010.pdf (126.01 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-00493412 , version 1 (18-06-2010)

Identifiers

Cite

Florence Faurez, Daniel Dory, Vincent Le Moigne, Rodolphe Gravier, André Jestin. Biosafety of DNA vaccines: New generation of DNA vectors and current knowledge on the fate of plasmids after injection.. Vaccine, 2010, 28 (23), pp.3888-95. ⟨10.1016/j.vaccine.2010.03.040⟩. ⟨hal-00493412⟩

Collections

ANSES
456 View
1871 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More