Combined in silico and in vitro approaches to identify P‐glycoprotein‐inhibiting pesticides - Anses - Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail Accéder directement au contenu
Article Dans Une Revue Journal of Biochemical and Molecular Toxicology Année : 2024

Combined in silico and in vitro approaches to identify P‐glycoprotein‐inhibiting pesticides

Résumé

The P-glycoprotein (P-gp) efflux pump plays a major role in xenobiotic detoxification. The inhibition of its activity by environmental contaminants remains however rather little characterised. The present study was designed to develop a combination of different approaches to identify P-gp inhibitors among a large number of pesticides using in silico and in vitro models. First, the prediction performance of four web tools was evaluated alone or in combination using a set of recently marketed drugs.
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Origine : Publication financée par une institution
Licence : CC BY - Paternité

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anses-04311433 , version 1 (28-11-2023)

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Nelly Guéniche, Zeineb Lakehal, Denis Habauzit, Arnaud Bruyère, Olivier Fardel, et al.. Combined in silico and in vitro approaches to identify P‐glycoprotein‐inhibiting pesticides. Journal of Biochemical and Molecular Toxicology, 2024, 38 (1), pp.e23588. ⟨10.1002/jbt.23588⟩. ⟨anses-04311433⟩
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